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GM GlobalTIS Keygen - GET WM.This invention relates to certain sodium salts of 3-aminopropionic acid in which one of the amine groups is mono-substituted with an iminoalkyl group. Additionally, this invention relates to a process for preparing such salts, and a pharmaceutical composition containing such salts in a physiologically acceptable solvent.
Compounds of this invention have been found to be useful in the treatment of NIDDM (non insulin dependent diabetes mellitus) and atherosclerosis. The compounds of this invention are substituted iminoalkyl derivatives of 3-amino-propionic acid which are useful as hypoglycemic agents in mammals, including man.
The compounds of this invention are also useful in the treatment of dyslipidemia. Dyslipidemia is characterized by elevated total serum cholesterol, LDL-cholesterol and/or VLDL-cholesterol and/or elevated triglycerides or lowered HDL-cholesterol.
The compounds of this invention are also useful in the treatment of atherosclerosis. Atherosclerosis is characterized by a progressive lesion of the arterial wall. It is a disease of mammals. While the exact mechanism is unknown, the lesion appears to be due to the accumulation of lipids and fibrous material in the extracellular matrix of the arterial wall.
The compounds of this invention are useful in the treatment of NIDDM (non insulin dependent diabetes mellitus) in mammals, including man.
Glucagon is a pancreatic hormone that stimulates hepatic glycogenolysis and gluconeogenesis, augments cyclic 3',5'-adenosine monophosphate (cAMP) production, promotes lipolysis in adipocytes, increases myocardial contractility, and is a potent vasodilator [see Hancock et al. (1958) J. Lab. Clin. Med. 49, 145-151; and Barra et al. (1960) Endocrinology 65, 493-499]. Glucagon receptors are present in the brain [see De Vivo et al. (1986) Diabetes 35, 260-264] and in the muscle [see Krause et al. (1989) Diabetes 38, 836-842].
Glucagon is known to be present in the human body. Glucagon may act as a feeding stimulant and as a mediator of hepatic glucose production [see Berggren et al. (1981) Diabetologia 0b46394aab
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