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FalseFalseFalseFalseFalseFalseFalseFalse-negative. A negative result was found when a treatment was expected to be effective or avoidable, but is not (also called false-positive).True-positive. A positive result was found when a treatment was ineffective or unavoidable.True-negative. A negative result was found when a treatment was expected to be effective and avoidable, but is not.False-positive. A positive result was found when a treatment was ineffective or unavoidable.False-negative. A negative result was found when a treatment was expected to be effective and avoidable, but is not.First-order sensitivity. (i) Positive predictive value. The ratio of true-positives to the number of true-positives plus false-positives. (ii) Negative predictive value. The ratio of true-negatives to the number of true-negatives plus false-negatives.Defining a state of "case" as having positive titer tests, positive antinuclear antibody test results, and classic serological evidence of ongoing SLE, these study design elements demonstrate a high sensitivity for each test (93%, 99%, and 99%, respectively). The negative predictive value (NPV) for each test is excellent at 92%, 96%, and 99%, respectively.

Abstract

Data from the New York University Lupus Registry (NYULR) were compared with data from the American College of Rheumatology (ACR) registry to identify correlates of SLE outcome in a tertiary care lupus population. New York patients are younger and have a shorter duration of disease, fewer physical disabilities, more antiphospholipid syndrome (APS) positivity, and a higher incidence of renal and central nervous system (CNS) involvement than seen in the general population of SLE patients.A retrospective chart review of the NYULR database was performed to identify characteristics of SLE patients seen at a single tertiary referral center between January 2000 and October 2007. Eighty-four percent of patients had a diagnosis of SLE made at the time of chart review. There were 590 patients in the registry. Demographic characteristics, disease manifestations, organ system involvement, and therapy were evaluated to determine the impact on disease activity and damage scores. The impact of comorbidities and medications on SLE outcome were also evaluated.Compared with the ACR registry, the NYULR patients had higher disease activity and damage scores, a higher incidence of CNS, renal, hematologic, and APS-related disease, and were younger. In the NYULR, less than 10% of patients were not treated with any form of immunosuppressive therapy, compared with 22% in the ACR registry. Almost 75% of patients were treated with anti-malarials, compared with 62% in the ACR registry.Patients with shorter disease duration, white race, absence of CNS, renal, hematologic, 0b46394aab

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